Mice were monitored for 30 d for adverse side effects, blood glucose, and insulin requirements. Aug 6, NudE and NudEL are related proteins that interact with cytoplasmic Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't. Anderson Cancer Center, Houston.
However, presumably because of a lack of certain hair keratins, the hair shafts that are generated twist and coil in the hair follicle infundibulum, which becomes dilated. In mice, rats, and humans, loss of function of Foxn1, a member of the winged helix/forkhead family of transcription factors, leads to macroscopic nudity and an . Transplants of human tumors in nude mice have shown a progressive increase during the past 15 years as an experimental model for cancer research.
Their functional relationship and involvement in LIS1 and dynein regulation are not completely understood. NudE and NudEL are related proteins that interact with cytoplasmic dynein and LIS1. Their functional relationship and involvement in LIS1 and dynein regulation . Mutations in the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in severely compromised immune system.
To evaluate the utility of nude mouse xenografts as preclinical drug screens, the activity of ten established chemotherapeutic agents was evaluated against seven melanoma and three ovarian carcinoma xenografts. Xenografts were established using primary explants from patients who had not received chemotherapy and serially passaged as sc tumors in nude mice. Plots of relative tumor growth versus time were nearly log-linear.
Infarct-kidney hypertension was induced in congenital athymic nude rats, and in their immunologically normal haired littermates. Nov 15, Brain alteration in a Nude/SCID fetus carrying FOXN1 homozygous mutation. Amorosi S(1) Case Reports; Research Support, Non-U.S. Gov't.
Nov 6, RAGE-aptamer Attenuates the Growth and Liver Metastasis of Malignant Melanoma in Nude Mice. Research Support, Non-U.S. Gov't.
Use of nude mouse xenografts as preclinical drug screens: in vivo activity of Comparative Study; Research Support, Non-U.S. Gov't; Research Support, U.S.
Mutations in the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in Research Support, U.S. Gov't, P.H.S.